Even if you’ve never heard of it before, hormone sensitive lipase can help you lose weight.
But wait a minute… what is hormone sensitive lipase anyway?
It’s not a new diet craze or fitness plan, but a little switch inside of you that can help you lose the extra fat that has been weighing you down.
It’s incredible just how powerful this obsession with getting lean is. From ancient folk remedies to hard-to-maintain diet and exercise plans, our species is obsessed with trying out new ways to stay thin.
Unfortunately, most of what we’ve come up with doesn’t work.
Thankfully, science has some useful insights into how we can lose weight and keep it off. You may be familiar with some basic principles, but I’d bet you’re not familiar with a little thing inside of you that can help you burn more fat.
It’s a very special enzyme called hormone sensitive lipase.
What is this Hormone-Sensitive Lipase?
Hormone sensitive lipase is a complex chemically structured enzyme that acts as a catalyst for the hydrolysis of fat in your body.
Simply put, it virtually “busts” your fat deposits.
The levels of hormone-sensitive lipase (HSL) in your body are inversely proportional to the serum levels of insulin. What this means is that as the levels of HSL decrease, the insulin levels in your blood increase.
This is bad because it slows down the fat burning process and deposits more fat throughout your body.
With this in mind, you want your HSL levels to stay at a healthy level. But how do you maintain that?
3 Clever Ways to Increase HSL Levels and Burn More Fat
Here are a few ways to get your metabolism cranking and increase the available HSL levels in your body:
1. Intermittent Fasting
Intermittent fasting is a great way to turbo charge fat loss.
Intermittent fasting increases the levels of fat loss enzymes and hormones in the body. Fasting also boosts up two very crucial fat burning enzymes in the body: the muscle-tissue based ipoprotein lipase and our friend hormone-sensitive lipase.
Both these enzymes catapult the fat burning by stimulating the cells to take up fat.
If you think going to the gym for an hour a day will help you get slim, I have some bad news for you:
Exercising every day has little effect on the fat burning capacity of the body if you’re sitting down better part of the day.
Studies done on rats have demonstrated that lipoprotein lipase and hormone-sensitive lipase are released from the leg muscles only when they are actively flexed or are contracting.
What this means is that hormone-sensitive lipase will only be released from your leg muscles when you’re standing.
Standing while working or watching TV may seem odd, but it is beneficial for the body. It releases more of the hormone-sensitive lipase which burns fat and makes the body leaner and fitter.
3. High-Intensity Training
Sustained aerobic activity for longer than 15 to 20 minutes mobilizes fat from your bodily fat stores in response to decreasing glycogen levels in the blood.
With decreased blood sugar levels, your insulin levels are depleted, thus triggering an increase of HSL.
What does all of this mean? It means that high-intensity interval training will boost your HSL levels and help you burn fat.
An added benefit of high-intensity exercise is that it results in a phenomenon called EPOC (Excess Post-exercise Oxygen Consumption).
This causes the body to have a sustained oxygen deficit that takes a long time to be fulfilled after the exercise session is over.
This may take up to 24 to 36 hours, thus burning more calories at that time as compared to a normal rest day.
With these things in mind, you can take advantage of your natural store of hormone-sensitive lipase as a weapon against the fat you’ve been so desperately trying to get rid of.
It’s further proof that your body has everything it needs to straighten itself out. Take care of it and it will take care of you!
1. Fredric B. Kraemer, Shen W.J (2002). Hormone-sensitive lipase control of intracellular tri-(di-) acylglycerol and cholesteryl ester hydrolysis. The Journal of Lipid Research. 43. 1585-1594.
2. Meijssen S, Cabezas MC, Ballieux CG, Derksen RJ, Bilecen S, Erkelens DW(2001). Insulin mediated inhibition of hormone sensitive lipase activity in vivo in relation to endogenous catecholamines in healthy subjects. J Clin Endocrinol Metab. 86. 4193-7.
3. Fredric B. Kraemer (2006). Hormone-Sensitive Lipase Knockouts. Nutrition & Metabolism. 3,12
4. Hormone sensitive lipase: structure, function and regulation. http://demeijer.com/
5. Peter Stralfors, Rupert C. Honnor (1989). Insulin-induced dephosphorylation of hormone-sensitive lipase. Eur. J. Biochem. 182, 379-385
6. Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E (2005). Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr. 81 (1):69-73.
Yuri Elkaim is one of the world’s most trusted health and fitness experts. A former pro soccer player turned NYT bestselling author of The All-Day Energy Diet and The All-Day Fat Burning Diet, his clear, science-backed advice has transformed the lives of more than 500,000 men and women and he’s on a mission to help 100 million people by 2040. Read his inspiring story, “From Soccer to Bed to No Hair on My Head” that started it all.